Clinical features of rhino-orbital-cerebral mucormycosis with bilateral cranial nerves paralyze as the clinical manifestation(report of one case)
10.3969/j.issn.1004-1648.2024.02.012
- VernacularTitle:以双侧颅神经麻痹为临床表现的鼻眶脑毛霉菌病的临床特点(附1例报告)
- Author:
Xiaoyu ZHENG
1
;
Hongna YANG
;
Wei FANG
Author Information
1. 250000 济南,山东大学山东省立医院重症医学科
- Keywords:
rhino-orbito-cerebral mucormycosis;
bilateral cranial nerves paralysis;
brain herniation;
next-generation sequencing;
diabetic ketoacidosis
- From:
Journal of Clinical Neurology
2024;37(2):109-112
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features of rhino-orbital-cerebral mucormycosis(ROCM)with bilateral cranial nerve palsies as the clinical manifestation.Methods The related clinical data about ROCM with bilateral cranial nerve palsy as a clinical manifestation was collected,analyzed as well as discussed in the manuscript.And the relevant literatures were reviewed.Results This patient was a healthy young man with new-onset diabetes and diabetic ketoacidosis.The patient developed rapidly with acute onset,bilateral blindness,blepharoptosis and extraocular muscle paralysis.The presence of mucormycosis was confirmed by CSF second-generation sequencing,fungal fluorescent staining and culture.Although effective antifungal therapy was performed early,but the patient quickly presented with cerebral hemorrhage and herniation.Eventually,the patient died after discharge.Conclusions ROCM is a rare and high-mortality infectious disease.This case indicated that the clinicians should consider the presence of ROCM in patients with diabetes/diabetic ketoacidosis when the bilateral cranial nerves paralysis are the clinical symptom,whicn can not be explained by other lesions.CSF next-generation sequencing is helpful for rapid diagnosis.
