Research progress on the regulation of cognitive decline by microglia in aging
10.3969/j.issn.1004-1648.2024.01.019
- VernacularTitle:衰老中小胶质细胞对认知功能减退调控的研究进展
- Author:
Lei YE
1
;
Shu SHU
;
Yun XU
Author Information
1. 210008 南京大学医学院附属鼓楼医院神经内科
- Keywords:
aging;
cognitive impairment;
microglia;
neuroinflammation
- From:
Journal of Clinical Neurology
2024;37(1):65-68
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of dementia increased significantly in the context of an aging population,imposing a significant burden on the economy and society.Therefore,finding the specific mechanism underlying cognitive decline in aging is of paramount significance.Recently,the role of microglia in the initiation and progression of cognitive decline in aging has become a research hotspot.Microglia,the resident immune cells of CNS,play important roles in immunosurveillance,synaptic pruning,damage repair and maintaining immune homeostasis.However,microglia undergo a variety of changes in cell morphology,gene expression and functional status with aging.This article review the impact of normal aging on microglia and the role of microglia in the pathogenesis of cognitive decline in aging,to provide a novel strategy for slowing or preventing the onset of dementia.
