Meta-analysis of efficacy and safety of intravenous combined with intrathecal/intraventricular injection of polymyxin against intracranial infection with multidrug-resistant bacteria
10.3969/j.issn.1004-1648.2024.01.005
- VernacularTitle:静脉滴注联合鞘内/脑室内注射多粘菌素治疗颅内多重耐药菌感染有效性和安全性的Meta分析
- Author:
Yiyi ZHOU
1
;
Yong LONG
;
Zunchun XIE
Author Information
1. 330006 南昌大学江西医学院第一附属医院神经内科
- Keywords:
polymyxin;
encephalitis;
intrathecal injection;
intraventricular injection;
Meta analysis
- From:
Journal of Clinical Neurology
2024;37(1):15-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective Evaluation of the efficacy and safety of intravenous(IV)combined with intrathecal/intraventricular injection(ITH/IVT)of polymyxin against intracranial infection with multidrug-resistant bacteria.Methods The databases,including Wanfang,VIP,Chinese Biomedical Literature,Pubmed,Embase,ScienceDirect,and Cochrane Library were searched,case-control studies on IV+ITH/IVT polymyxin against intracranial infection with multidrug-resistant bacteria by January 2023 were screen.RevMan 5.4 software was used for meta-analysis.Results A total of 9 retrospective studies were included.The fatality rate in IV+ITH/IVT polymyxin group was significantly lower than that in IV group(OR =0.19,95%CI:0.11-0.35,P＜0.01).There was no significant difference in ICU hospitalization days(OR =-2.32,95%CI:-23.59-18.89,P =0.83)and adverse reaction rate(OR =0.93,95%CI:0.26-3.38,P =0.91)between IV+ITH/IVT group and IV group.Conclusion IV+ITH/IVT polymyxin in treating the intracranial infection with multidrug-resistant bacteria can significantly reduce fatality rate,and does not significantly increase adverse reactions.
