Clinical features of Guillain-Barré syndrome with positive anti sulfatide antibody in CSF and hyponatremia(report of one case)
10.3969/j.issn.1004-1648.2023.06.019
- VernacularTitle:伴低钠血症脑脊液抗Sufatide抗体阳性Guillain-Barré综合征的临床特点(附1例报告)
- Author:
Yuanliang DING
1
;
Lingling WANG
;
Ailiang MIAO
Author Information
1. 210029 南京医科大学附属脑科医院重症医学科
- Keywords:
Guillain-Barré syndrome;
anti sulfatide antibody;
immunoglobin;
hyponatremia;
severe pain
- From:
Journal of Clinical Neurology
2023;36(6):462-465
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the diagnosis and treatment experience of patients with Guillain-Barré syndrome(GBS)with positive anti sulfatide antibody in CSF.Methods The clinical data of a case of patient with GBS with positive anti sulfatide antibody in CSF in Department of Neurology,The Affiliated Brain Hospital of Nanjing Medical University in January,2023 were retrospectively analyzed,and the relevant literatures were reviewed.Results Two cases with GBS with positive anti sulfatide antibody in CSF from 2 literatures were retrieved,a total of 3 cases were retrieved.All cases were males.The onset duration was 4-6 d.Two patients with GBS with positive anti-sufatide antibody in CSF developed limb weakness,severe back and limb pain.Albuminocytologic dissociation in CSF and inefficacy of immunoglobin were found in the two cases.Severe hyponatremia secondary to intravenous immunoglobin was observed in our case.One patient presented with cranial nerve damage with mild elevation of CSF protein and improvement after immunoglobulin.Conclusion The plasmapheresis was recommended for the patients presenting with limb weakness with positive anti-sulfatide antibody in CSF in order to prevent inefficacy and severe hyponatremia secondary to intravenous immunoglobin.
