Research progress on role of peroxisome proliferator-activated receptor-γ in neuropathic pain
- VernacularTitle:过氧化物酶体增殖物激活受体-γ在神经病理性疼痛中作用的研究进展
- Author:
Peng YUAN
1
;
Daoyun LEI
;
Yingqiao NIU
;
Yunqing ZHU
;
Wei ZHU
Author Information
- Keywords: Peroxisome proliferator-activated receptor-γ; Neuropathic pain; Neuroinflammation; Oxidative stress
- From: The Journal of Clinical Anesthesiology 2024;40(1):85-88
- CountryChina
- Language:Chinese
- Abstract: Neuropathic pain(NP)is caused by leision or disease of the somatic sensory nervous system,and its pathological mechanism is complex,mainly related to abnormal neural structure and function.It is hard for existing treatment methods to obtain satisfactory results.With the deepening of the study of peroxisome proliferate activation receptor-γ(PPAR-γ),its role in neuroinflammation,oxidative stress,ion channels,mitochondrial function,neuroprotection and other aspects have been discovered succes-sively,PPAR-γ may be one new target for pain prevention and treatment.This paper reviews the role of PPAR-γ in NP and related mechanisms,in order to provide new thinking for the clinical treatment of NP.
