Distribution characteristics of sIgE antibodies against four components of egg white in children with egg allergy
10.13602/j.cnki.jcls.2024.01.01
- VernacularTitle:鸡蛋过敏患儿蛋清4种组分sIgE抗体分布特征
- Author:
Yuanmin SUN
1
;
Xin TAN
;
Lisheng ZHENG
;
Bei ZHANG
;
Xiaohui YANG
;
Yang YU
;
Huiqiang LI
Author Information
1. 天津医科大学医学检验学院,天津 300203
- Keywords:
egg allergy;
component-resolved diagnostics;
egg white allergen component;
specific IgE antibody;
distribution character-istics
- From:
Chinese Journal of Clinical Laboratory Science
2024;42(1):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution characteristics of serum sIgE antibodies against four allergenic protein components of egg white in children with egg allergy,and then clarify the clinical application value of single component-resolved diagnostics of egg allergy.Methods Serum samples from 197 children with egg allergy were collected.The levels of serum sIgE antibodies against four major allergenic protein components of egg white,including ovomucin,ovalbumin,ovotransferrin,and lysozyme,were detected by the light-excited chemiluminescence assay(LiCA),and the distribution characteristics of sIgE antibodies were analyzed.Results The positive rates of serum sIgE antibodies against ovalbumin,ovomucin,ovotransferrin,and lysozyme in 197 chlidren with egg allergy were 77.16%(152/197),70.56%(139/197),35.02%(69/197),and 18.27%(36/197),respectively.The positive rate of serum sIgE antibody against both ovomucin and ovalbumin was 30.45%.There was a weak correlation between the levels of sIgE antibodies against egg and the cumulative levels of sIgE antibodies against four allergenic protein components(r=0.266 8,P＜0.05).There were signifi-cant individual differences in the levels of serum sIgE antibodies against four allergenic protein components of egg white in the children with egg allergy.Conclusion There is individual heterogeneity in the levels of serum sIgE antibodies against four components of egg white in the children with egg allergy.The detection of sIgE antibodies against egg white components can distinguish different forms of egg allergies,which is of great value for the accurate diagnosis and precise desensitization of children's egg allergy.
