Research Progress of Iron Death in Cardiomyopathy

VernacularTitle:铁死亡在心肌病中的研究进展
Author: Wei LI ¹ ; Lihong JIANG ; Lijing MA ; Rui CHEN ; Tongshuo YANG
Author Information

1. 昆明医科大学附属延安医院心外科,云南昆明 650051
Keywords: Cardiomyopathy; Ferroptosis; Cell death; Iron metabolism
From: Journal of Kunming Medical University 2024;45(3):180-185
CountryChina
Language:Chinese
Abstract: Cardiomyopathy is a group of heterogeneous myocardial diseases with a variety of specific phenotypes that can lead to cardiovascular death or progressive heart failure in severe cases.Because of the severity and complexity of these diseases,the search for new regulatory mechanisms to prevent and treat cardiomyopathy is particularly urgent.Iron death is a form of programmed cell death that differs from other forms of iron dependence and is characterized by the accumulation of iron-dependent lipid peroxides.Studies have shown that iron death can be involved in the occurrence and progression of cardiomyopathy through different signaling pathways.Therefore,targeted regulation of iron death is a new strategy to prevent cardiomyopathy.In this paper,the mechanism of iron death and its important role in cardiomyopathy were reviewed to find the potential relationship between iron death and cardiomyopathy and provide more ideas for the treatment of various cardiomyopathies in the future.