Relationship between TGF-β/Smads Signaling Pathway and Cognitive Dysfunction in Patients with Aneurysmal Subarachnoid Hemorrhage
10.12259/j.issn.2095-610X.S20240319
- VernacularTitle:动脉瘤性蛛网膜下腔出血患者TGF-β/Smads信号转导通路与认知功能障碍的关系
- Author:
Yi HUANG
1
;
Yongjian HUANG
;
Ling MAI
;
Ting LUO
Author Information
1. 崇左市人民医院神经外科,广西 崇左 532200
- Keywords:
Aneurysmal subarachnoid hemorrhage;
TGF-β/Smads signaling pathway;
Cognitive dysfunction
- From:
Journal of Kunming Medical University
2024;45(3):127-132
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between factors related to the transforming growth factor β(TGF-β)/Aerine-threonine kinase receptors(Smads)signaling pathway and cognitive dysfunction in peripheral blood of patients with aneurysmal subarachnoid hemorrhage(aSAH).Methods The clinical data of 100 patients with aSAH admitted to Chongzuo City People's Hospital from October 2018 to March 2022 were retrospectively selected and grouped according to the patients'Montreal Cognitive Assessment Scale(MoCA)scores,including 54 cases with cognitive dysfunction and 46 cases without cognitive dysfunction.The clinical data,peripheral blood TGF-β,Smad1,Smad3,and Smad7 mRNA expression levels of the two groups were compared.The relationship between pathway-related factors and cognitive dysfunction in patients with aSAH was analyzed in a multifactorial manner.The predictive value of pathway-related factors for cognitive dysfunction in aSAH patients was assessed using the receiver operating characteristic(ROC)curve.Results Peripheral blood TGF-β,Smad1,Smad3,and Smad7 mRNA expression levels were higher in the cognitively impaired group than in the group without cognitive impairment(P<0.05).Multifactorial showed that pathway-related factors were significantly associated with cognitive impairment in patients with aSAH(P<0.05).The ROC showed that the area under the curve(AUC)of pathway-related factors jointly predicted cognitive dysfunction in patients with aSAH was superior to that predicted alone(P<0.05).Conclusion The high expression of factors related to the TGF-β/Smads signaling pathway in the peripheral blood of aSAH patients suggests that this pathway may be associated with cognitive dysfunction in patients.
