Value of Head and Neck 4D-CTA Combined with SDF-1a/CXCR4 Signaling Pathway in Assessing the Risk of Ruptured Intracranial Posterior Communicating Aneurysms
10.12259/j.issn.2095-610X.S20240309
- VernacularTitle:头颈4D-CTA结合SDF-1a/CXCR4信号通路评估颅内后交通动脉瘤破裂风险的价值
- Author:
Yiming XU
1
;
Jianfeng ZHONG
;
Bin LI
;
Xinyan ZHOU
;
Hongli ZHU
;
Jing LIANG
;
Chengde LIAO
Author Information
1. 昆明市延安医院放射科,云南 昆明 650051
- Keywords:
4D-CTA;
SDF-1a;
Ruptured posterior intracranial communicating aneurysm
- From:
Journal of Kunming Medical University
2024;45(3):59-64
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of 4D-CTA combined with SDF-1a/CXCR4 signaling pathway in evaluating the risk of intracranial aneurysm rupture.Methods Fifty patients with unruptured intracranial posterior communicating aneurysms and 50 patients with ruptured intracranial posterior communicating aneurysms were divided into unruptured group 1 and ruptured group 1.All patients underwent 4D-CTA examination and serumSDF-1alevel was detected.Non-ruptured group 1 was followed up for 12 months(After conservative treatment),on this basis,patients with ruptured posterior communicating aneurysms were included in ruptured group 2,and patients with unruptured posterior communicating aneurysms were included in non-ruptured group 2.Results The AUC values of Wn,AR,L,SR,SDF-1a and their combinations in diagnosing ruptured intracranial posterior communicating aneurysms were all greater than 0.70.The AUC values of Wn,AR,L,SR,SDF-1a and their combinations in predicting ruptured intracranial posterior communicating aneurysms in ruptured group 2 were all greater than 0.70.Conclusion 4D-CTA combined with SDF-1acan effectively distinguish ruptured intracranial posterior communicating aneurysms and predict the risk of rupture.
