Identification of Atrial Fibrillation-related Inflammatory Genes and Their Association with Immune Cell Infiltration Based on Comprehensive Bioinformatic Analysis
10.12259/j.issn.2095-610X.S20240303
- VernacularTitle:基于综合生物信息分析鉴定心房颤动相关炎症基因及其与免疫细胞浸润的关联
- Author:
Man YANG
1
;
Xingan ZHAO
;
Yunna GE
;
Juan QIN
;
Xiya WANG
;
Siming TAO
Author Information
1. 大理大学临床医学院/大理市第一人民医院心内科,云南 大理 671000
- Keywords:
Atrial fibrillation;
Bioinformatics analysis;
Immune infiltration;
Inflammatory response;
Biomarkers
- From:
Journal of Kunming Medical University
2024;45(3):18-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify inflammation-related genes in atrial fibrillation(AF)and explore the possible role and mechanism of these genes and infiltrating immune cells in the development of AF.Methods A series of bioinformatics analysis combined with machine learning algorithms to identify biomarkers of AF,the receiver operating characteristic(ROC)curves were used to verify the prediction and diagnostic value of key genes,and Spearman correlation analysis was used to clarify the correlation between key genes and infiltrating immune cells.Results 593 differential genes(| log2(fold change,FC)|>1,P<0.05),7 immune cell subtypes(P<0.05)were selected,190 immune-related differential genes were obtained,3 biomarkers(IGF1,PTGS 2 and PPARG),and the correlation analysis showed that 3 markers were significantly associated with infiltrating immune cells(P<0.05).Conclusion IGF1,PTGS2 and PPARG are inflammation-related genes of AF,which are speculated to be closely related to the process and pathway of immune cell infiltration.
