Association of Polymorphisms in the 3'UTR of Genes in the ERK1/2 Signaling Pathway with Non-small Cell Lung Cancer
10.12259/j.issn.2095-610X.S20240302
- VernacularTitle:ERK1/2信号通路基因3'UTR多态性与非小细胞肺癌的相关性
- Author:
Chao HONG
1
;
Xudong XIANG
;
Yingfu LI
;
Yang CAO
;
Xueya CHEN
;
Shuai LI
;
Anhao XING
;
Mu LIN
;
Qianli MA
Author Information
1. 中国医学科学院 & 北京协和医学院医学生物学研究所,云南 昆明 650118
- Keywords:
Non-small cell lung cancer;
ERK1/2 signaling pathway;
SNP;
3'UTR;
MAPK1
- From:
Journal of Kunming Medical University
2024;45(3):7-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between four single nucleotide polymorphisms(SNP)(rs9340 in MAPK1,rs14804 in NRAS,rs712 and rs7973450 in KRAS)in the 3'UTR of ERK1/2 signaling pathway-related genes and non-small cell lung cancer(NSCLC).Methods A total of 478 NSCLC patients and 480 healthy controls were enrolled in this study.Four SNPs were genotyped by using TaqMan assays.The association between the four SNPs and NSCLC was analyzed.Results The distribution frequency difference of the allele of rs9340 was statistically significant between the control group and the non-small cell squamous cell carcinoma(SCC)group(P = 0.009),suggesting that the G allele of rs9340 may be a protective factor for non-small cell lung squamous cell carcinoma(OR = 0.67,95%CI:0.50～0.91).In addition,in the<50 years age group,the distribution frequency difference of the allele of rs9340 was statistically significant between the control group and the NSCLC group(P = 5.07×10-4),indicating that the G allele of rs9340 may be a protective factor for NSCLC(OR = 0.46,95%CI:0.29～0.72).Conclusion The SNP rs9340 in MAPK1 may be associated with the risk of NSCLC.
