Research Progress on the Anti-tumor Activity and Mechanism of Narciclasine
10.12259/j.issn.2095-610X.S20240222
- VernacularTitle:水仙环素的抗肿瘤活性及机制研究进展
- Author:
Min YANG
1
;
Qiqi LIN
;
Dandan LIU
;
Hongyu ZHOU
Author Information
1. 昆明医科大学药学院暨云南省天然药物药理重点实验室,云南 昆明 650500
- Keywords:
Narciclasine;
Hymenocallis Littoralis Alkaloids;
Antitumor Activity;
Molecular Mechanism
- From:
Journal of Kunming Medical University
2024;45(2):153-159
- CountryChina
- Language:Chinese
-
Abstract:
Narciclasine(NCS),a hymenocallis littoralis alkaloid extracted from the bulbs of the genus Narcissus in the Lycoriaceae family,has been proven to have significant anti-tumor activity against a variety of tumor cells.The antitumor mechanisms of NCS are diverse and NCS exhibits antitumor effects through different pathways,which adapts to the current trend of developing multi-target anti-tumor drugs.This review introduces the research progress of the anti-tumor activity and mechanism of NCS in recent years based on the inhibitory effect of NCS on gastric cancer cells,oral cancer cells,polymorphous glioblastoma cells,colon cancer cells,breast cancer cells,melanoma cells and primary exudative lymphoma cells,aiming to provide ideas and references for the research and development,and design of NCS type anti-tumor drugs in the future.
