Effect of Nicorandil on Inflammation-related Markers after PCI Intervention in Patients with Acute Coronary Syndromes
10.12259/j.issn.2095-610X.S20240219
- VernacularTitle:尼可地尔对急性冠脉综合征患者PCI介入治疗后炎性相关指标的影响
- Author:
Xiaodong ZHANG
1
,
2
;
Nan NIU
;
Ying LIU
;
Jiajie MEI
;
Zhaohong GENG
;
Hongyan WANG
Author Information
1. 大连医科大学附属第二医院心内科 116023
2. 大连医科大学附属第一医院心力衰竭与结构性心脏病科,辽宁 大连 116011
- Keywords:
Acute coronary syndrome;
Inflammatory indicators;
Nicorandil
- From:
Journal of Kunming Medical University
2024;45(2):136-140
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of treatment with nicorandil after Percutaneous Coronary Intervention(PCI)in patients with Acute Coronary Syndrome(ACS)on inflammation-related markers,and to assess its effects on vascular endothelial function.Methods Sixty-six ACS patients who underwent PCI in the Department of Cardiovascular Medicine of the Second Affiliated Hospital of Dalian Medical University from August 2022 to January 2023 were used as the study sample,and were divided into the control group and the experimental group according to the method of completely randomized design,with 33 cases in each group.The control group was treated with conventional therapy,and the experimental group was treated with nicorandil.Inflammatory indexes,homocysteine(Hcy)and adverse reactions in serum were compared between the two groups.Results After nicorandil treatment,the levels of postoperative inflammation-related factors in the control group were higher than that in the experimental group,and the difference was statistically significant(P<0.05);The levels of Hcy after nicorandil treatment were lower than that in the control group,and the difference was statistically significant(P<0.05);and the rate of adverse reactions in the experimental group was higher than that in the control group,and there was no statistical difference(P>0.05).Conclusion Nicorandil application in elderly ACS patients after PCI has a definite efficacy,can optimize the vascular-related inflammatory indexes,reduce homocysteine levels to improve coronary vascular endothelial function,and is suitable for further promotion.
