Comparison of Four Methods in the Diagnosis of Bone Tuberculosis
10.12259/j.issn.2095-610X.S20240218
- VernacularTitle:4种检测方法对骨结核的诊断价值比较
- Author:
Xiaoqin LI
1
;
Zhiqiang MA
;
Nan TIAN
;
Wei CHEN
;
Caixin LI
;
Min ZHOU
Author Information
1. 昆明市第三人民医院检验科/云南省传染性疾病临床医学中心,云南 昆明 650031
- Keywords:
Smear acid-fast staining;
TB-DNA;
Xpert/MTB/RIF;
Culture of mycobacterium;
Tuberculosis bone
- From:
Journal of Kunming Medical University
2024;45(2):131-135
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the diagnostic value of smear acid-fast staining,TB-DNA,X-pert MTB/RIF and culture of Mycobacterium tuberculosis.Methods Four methods were used to detect the perifocal pus of the patients with bone destruction in orthopaedics department within one year,and the results were analyzed statistically,the indexes included sensitivity,specificity,positive predictive value and negative predictive value.Results The sensitivity,specificity,positive predictive value,negative predictive value,and Youden index were 31.75%,100.00%,100.00%,53.74%and 0.32 respectively.TB-DNA had a sensitivity of 88.89%,a specificity of 98.00%,a positive predictive value of 98.25%,a negative predictive value of 87.50%,and a Youden Index of 0.87.Xpert MTB/Rif had a sensitivity of 95.23%,a specificity of 68.00%,and a positive predictive value of 78.95%,the negative predictive value was 91.90%,the Youden index was 0.63.The sensitivity,the specificity,the positive predictive value,the negative predictive value and the Youden index were 41.27%,100.00%,100.00%,57.47%and 0.41 respectively,(χ2 = 77.354,P<0.005).Conclusion Among the four methods,TB-DNA has a good Sensitivity and specificity,Xpert mtbrif has a good sensitivity,TB-DNA and Xpert mtbrif ha a good authenticity,and both positive and negative predictive values are high,it has good value in the diagnosis of bone tuberculosis.
