Evaluation of Cardiac Toxicity of Anthracyclines in Children with Acute Leukemia Based on Tei Index
10.12259/j.issn.2095-610X.S20240216
- VernacularTitle:基于Tei指数评价蒽环类药物对急性白血病患儿心脏毒性的研究
- Author:
Xuemei CHEN
1
;
Pin GUO
;
Liufang CHUAN
;
Zi WANG
;
Xuejiao LI
;
Wenji HE
Author Information
1. 昆明医科大学第三附属医院/云南省肿瘤医院国家药物临床试验机构临床研究部(GCP办公室),云南 昆明 650118
- Keywords:
Anthracyclines;
Cardiac toxicity;
Cardiac ultrasound;
TeiS;
TeiRL;
TeiM;
TeiT
- From:
Journal of Kunming Medical University
2024;45(2):117-122
- CountryChina
- Language:Chinese
-
Abstract:
Objective To apply ultrasound to monitor cardiac function changes after anthracycline exposure in children with acute leukemia,in order to obtain the indicators of early changes in their cardiac function.Methods Children with acute leukemia from 2018 March to December 2020 in the Children's Hospital of Kunming Medical University were enrolled according to the inclusion and exclusion criteria,their routine cardiac ultrasound and tissue Doppler condition were recorded,and the changes in systolic function were evaluated by Tei index including TeiS,TeiRL,TeiM and TeiT.Results The mean values of LVEF in the normal and the experimental group were both above 60%.FS,SV,and EDV were all in the normal range.While common indicant,the index of TDI or Tei was not statistically significant(P>0.05).The levels of TeiM,TeiRL and TieT in the groups that received a total dose of 200 mg/m2 anthracyclines and 250 mg/m2 were significantly different from that before treatment(P<0.05).Conclusion Tei index can be utilized as a sensitive indicator for early changes in left and right heart function after children with acute leukemia are exposed to anthracyclines.
