Advances in Epigenetic Regulatory Mechanisms in HSV1 Infection
10.12259/j.issn.2095-610X.S20240129
- VernacularTitle:HSV1感染中的表观遗传调控机制研究进展
- Author:
Changjing WU
1
;
Yufang ZOU
;
Xinwei HUANG
Author Information
1. 昆明医科大学第二附属医院中心实验室,云南 昆明 650033
- Keywords:
Herpes simplex virus type 1;
Latency associated transcripts;
Epigenetic regulation;
Post-translational modifications of histone
- From:
Journal of Kunming Medical University
2024;45(1):172-178
- CountryChina
- Language:Chinese
-
Abstract:
Herpes simplex viruses type 1(HSV1)is among the most ubiquitous human pathogens that cause a wide variety of disease states.The latent infection of the central nervous system and sporadically reactivation is the central part of HSV1 pathogenesis,which also brings challenges to antiviral therapies.At present,the mechanism of establishing,maintaining and reactivation of HSV1 has not been fully clarified,whereas it has been generally accepted that the epigenetic regulation may play an important role.Accumulating researches have also indicated that the lytic and latent viral genomes exhibit the different chromatin structures,and the accumulation of diverse post-translational modifies the histones endow viral genes with transcriptional activation or repression features.In addition,the latency-associate transcripts of virus may also participate in the genome epigenetic modification.In this review,we summarize the research progress of epigenetic regulation of HSV1 and highlight the critical role of chromatin remodeling in HSV1 lytic proliferation and establishment of latent infection.
