Risk Factors of Recurrence in Patients with Ischemic Stroke Treated with Aspirin Single Drug Antiplatelet Therapy
10.12259/j.issn.2095-610X.S20240113
- VernacularTitle:阿司匹林单药抗血小板治疗的缺血性卒中患者复发危险因素分析
- Author:
Qian LI
1
;
Puqiong FENG
;
Qin YAO
;
Hanmei CHEN
;
Ting ZHAO
;
Hui WU
Author Information
1. 昆明医科大学第一附属医院临床药学中心,云南 昆明 650032
- Keywords:
Ischemic stroke;
Recurrence;
PEAR1 gene;
Homocysteine;
Risk factor
- From:
Journal of Kunming Medical University
2024;45(1):78-82
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors of relapse in patients with ischemic stroke using aspirin for single drug antiplatelet therapy.Methods A retrospective analysis was conducted on 200 patients with mild and medium ischemic stroke after 12 months of single drug treatment with aspirin,and the patients were divided into non-recurrence group and recurrence group according to the recurrence of stroke.Univariate analysis and multivariate logistic regression model were used to explore whether the related indicators were risk factors for recurrence.The ROC curve was used to predict the critical value of risk factors.Results Univariate analysis showed that platelet count,Hcy level and the A allele at rs12041331 site of PEAR1 gene were statistically significant risk factors(P<0.05).Multifactor analysis showed that the independent risk factor for recurrence was homocysteine level[OR = 1.16(1.089-1.240),P<0.001)].The critical value of ROC prediction was 8.35 μmol/L(sensitivity 0.847,specificity 0.532).Conclusions The Hcy level,platelet count and A allele at rs12041331 site of PEAR1 gene are risk factors for recurrence in patients with ischemic stroke treated with aspirin for Single drug antiplatelet therapy.Hcy level is independent risk factor and can be used to predict the risk of recurrence.
