Correlation Analysis of HLA-DM Gene Polymorphisms with Polio Vaccine-induced Antibody Response

VernacularTitle:HLA-DM基因多态性与脊髓灰质炎疫苗诱导抗体应答的相关性
Author: Runan QI ¹ ; Lei SHI ; Shuyuan LIU ; Jing LI ; Li SHI
Author Information

1. 中国医学科学院 & 北京协和医学院医学生物学研究所,云南昆明 650118
Keywords: HLA-DM; Gene polymorphism; Polio vaccine; Antibody response
From: Journal of Kunming Medical University 2024;45(1):8-14
CountryChina
Language:Chinese
Abstract: Objective To investigate the correlation between HLA-DM gene polymorphism and antibody response induced by poliomyelitis vaccine.Methods 355 healthy infants aged 2 to 3 months in Guangxi Zhuang Autonomous Region were selected as the study objects,and 10 SNPs of DMA exon 3 and DMB exon 2/3 were genotyped by Sanger sequencing.The correlation between DMA and DMB genes and poliomyelitis vaccine-induced antibody response was analyzed at allele,genotype and haplotype levels.Results In the type Ⅰ antibody response induced by polio vaccine,the frequencies of DMA*01:02,DMB*01:01,DMB*01:01/DMB*01:01 and DMA*01:02-DMB*01:01 were higher in the non-seroconversion group than in the seroconversion group(P<0.05).In the polio type Ⅱ antibody response,the frequencies of DMA*01:02,DMA*01:02/DMA*01:02,DMB*01:01/DMB*01:01 and DMA*01:02-DMB*01:01 were higher in the non-seroconversion group than in the seroconversion group(P<0.05).Conclusion Alleles DMA*01:02 and DMB*01:01 may be associated with type Ⅰ and type Ⅱ antibody responses induced by poliomyelitis vaccine.