Research Progress of miRNA in Non-alcoholic Fatty Liver Disease

VernacularTitle:miRNA在非酒精性脂肪性肝病中的研究进展
Author: Hang CHEN ^{1
,

2} ; Qi CUI ; Minshan HUANG ; Jianjun LIU ; Lanqing MA
Author Information

1. 昆明医科大学第一附属医院消化内科,云南省消化系统疾病研究所,云南省消化系统疾病临床研究中心,云南昆明 650032
2. 昆明医科大学生物医学工程研究院,云南昆明 650500
Keywords: Nonalcoholic fatty liver disease; miRNA; Insulin Resistance
From: Journal of Kunming Medical University 2024;45(1):1-7
CountryChina
Language:Chinese
Abstract: Nonalcoholic fatty liver disease(NAFLD)is the most common chronic liver disease,with a global prevalence of approximately 30.05% to 32.4% .It is closely associated with various other diseases.In recent years,microRNAs(miRNAs)have played a crucial role as non-invasive biomarkers in understanding the pathogenesis and diagnosis of NAFLD.miRNAs play significant roles in both lipid metabolism and insulin resistance,exerting specific regulatory functions in the development and progression of NAFLD.miRNAs are small RNA molecules that regulate the gene expression and protein synthesis by controlling the transcription and translation of target genes.This article provides a comprehensive overview of the roles and mechanisms of miRNAs in lipid metabolism,insulin resistance,and the occurrence and development of NAFLD.