Correlation of Preoperative Anemia Types with Pathological Features and Prognosis in Patients with Colorectal Cancer
10.12259/j.issn.2095-610X.S20231226
- VernacularTitle:术前不同贫血类型与结直肠癌患者病理特征及预后的相关性
- Author:
Houji GUO
1
;
Mei YANG
;
Zhongwei QIN
;
Zhanyi HUANG
Author Information
1. 右江民族医学院附属医院 肛肠外科,广西 百色 533000
- Keywords:
Radical resection of colorectal cancer;
Type of anemia;
Pathological features;
Prognosis
- From:
Journal of Kunming Medical University
2023;44(12):165-170
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between different types of anemia(small cell anemia and nor-mal cell anemia)before operation and pathological features and prognosis of colorectal cancer patients.Methods The clinical data of 130 patients with colorectal cancer who underwent radical surgery in our hospital from March 2018 to February 2021 were retrospectively analyzed.According to the morphology of red blood cells,the patients were divided into group A(70 cases without anemia),group B(18 cases with small cell anemia)and group C(42 cases with normal cell anemia).Pathological features and postoperative 2 a survival rate of the 3 groups were compared.The correlation between preoperative anemia types and pathological features of colorectal cancer was analyzed by Phi coefficient test,and Kaplan-Meier survival curve was drawn to compare the survival rate of the 3 groups.Results There were significant differences in gender,tumor site,tumor diameter and TNM stage distribution among the three groups(P<0.05).The Phi coefficient test showed that preoperative anemia type was correlated with gender,tumor site,tumor diameter,and TNM stage(r = 0.238,0.255,0.266,0.331,P = 0.025,0.015,0.010,0.001).Multivariate Logistic regression analysis showed that tumor diameter≥5 cm,TNM stage Ⅲ-Ⅳ,distant metastasis,lymph node metastasis,preoperative small cell anemia,preoperative normal cell anemia were the risk factors for the prognosis of colorectal cancer after radical surgery(OR>1,P<0.05).The overall survival rate of 2a in group A was higher than that in group C>that in group B(P<0.05).Log-rank test showed that the postoperative survival rate of the three groups was significantly different(P<0.05).Conclusion Preoperative anemia types were correlated with tumor site,tumor diameter,TNM stage and postoperative survival time of colorectal cancer patients,among which preoperative small-cell anemia patients had the lowest survival rate.
