The Serum CA-125 Concentration Data Assists in Evaluating CT Imaging Information When Used to Differentiate Borderline Ovarian Tumor from Malignant Epithelial Ovarian Tumors.
10.3348/kjr.2011.12.4.456
- Author:
Ji Eun SHIN
1
;
Hyuck Jae CHOI
;
Mi hyun KIM
;
Kyoung Sik CHO
Author Information
1. Department of Radiology and the Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, Korea. choihj@amc.seoul.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
CT;
Borderline ovarian tumor;
Malignant ovarian tumor;
CA-125
- MeSH:
Adenocarcinoma, Mucinous/*blood/pathology/*radiography;
Adolescent;
Adult;
Aged;
Biological Markers/blood;
CA-125 Antigen/*blood;
Contrast Media/diagnostic use;
Cystadenocarcinoma, Serous/*blood/pathology/*radiography;
Diagnosis, Differential;
Female;
Humans;
Middle Aged;
Neoplasm Staging;
Ovarian Neoplasms/*blood/pathology/*radiography;
Predictive Value of Tests;
ROC Curve;
Retrospective Studies
- From:Korean Journal of Radiology
2011;12(4):456-462
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: We wanted to evaluate the diagnostic value of serum CA-125 concentration, when used in combination with the preoperative contrast-enhanced CT results, to differentiate borderline ovarian tumors (BOTs) from stage I malignant epithelial ovarian tumors (MEOTs). MATERIALS AND METHODS: Ninety-eight masses (46 BOTs and 52 stage I MEOTs) from 87 consecutive patients (49 with BOTs and 38 with stage I MEOTs) who had undergone preoperative contrast-enhanced computed tomography (CT) and surgical staging were evaluated retrospectively and independently by two radiologists. The preoperative serum CA-125 concentration was measured in all patients. The utility of analyzing serum CA-125 concentration in combination with the CT results was evaluated by receiver operating characteristic (ROC) curve analysis. RESULTS: An irregular tumor surface and lymphadenopathy were predictive of a MEOT. ROC analysis showed that the combination of CT data and the serum CA-125 level resulted in a higher diagnostic performance than did using the CT alone for differentiating BOTs from MEOTs. The areas under the curves (AUCs) without and with the use of the serum CA-125 level data were 0.67 (95% confidence interval [CI]: 0.57-0.77) and 0.78 (95% CI: 0.68-0.85), respectively, for reader 1 (p = 0.029) and 0.71 (95% CI: 0.61-0.80) and 0.81 (95% CI: 0.72-0.89), respectively, for reader 2 (p = 0.009). CONCLUSION: The serum CA-125 concentration is of additional diagnostic value when used in conjunction with the CT imaging results for differentiating BOTs from MEOTs.
