Application of Pre-implantation Genetic Testing in the Patients with Turner Syndrome
10.12259/j.issn.2095-610X.S20231216
- VernacularTitle:胚胎植入前遗传学检测在Turner综合征患者中的临床应用
- Author:
Zhibiao CHEN
1
;
Qiuxiang HUANG
;
Lihua MAO
;
Guoyong CHEN
;
Yun LIU
;
Zhihong WANG
Author Information
1. 福建医科大学福总临床医学院(第九〇〇医院)妇产科生殖中心,福建 福州 350025
- Keywords:
Turner syndrome;
Assisted reproductive treatment;
Embryo;
Preimplantation genetic testing
- From:
Journal of Kunming Medical University
2023;44(12):100-105
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of pre-implantation genetic testing(PGT)in patients with Turner syndrome.Methods The clinical data,embryonic development,PGT results and pregnancy outcome of 18 patients with Turner syndrome who underwent PGT in the reproductive center of 900th Hospital from January 2016 to June 2023 were retrospectively analyzed.Results All 18 patients had spontaneous puberty development,of which 4 patients had primary ovarian insufficiency(POI).A total of 24 oocyte retrieval cycles were performed in 18 patients,of which 6 patients had no biopsied embryos for 10 cycles.Sixty-one embryos were biopsied and 60 embryos were clearly diagnosed,including 25 with chromosomal abnormalities.Seven patients with mosaic Turner syndrome obtained clinical pregnancies after transplantation,including 4 healthy boys had already been delivered and 3 are in pregnancy.Conclusion There are numerous types of karyotype in Turner syndrome.The clinical phenotypes vary greatly in individuals with Turner syndrome,and prognosis of PGT is significant different.Patients with Turner syndrome who had biopsied embryos can obtain available embryo using PGT,and achieve ideal clinical outcomes.
