A Study on Prognostic Value of Cellular Immunological Indicators in Omicron Variant Infected Elderly Severe Patients
10.12259/j.issn.2095-610X.S20231214
- VernacularTitle:奥密克戎变异株老年重症感染者细胞免疫指标对预后的价值研究
- Author:
Jiefu TANG
1
;
Dexing YANG
;
Shengzhe LIU
;
Qiang WANG
;
Kai FU
;
Zhenfang WANG
;
Ying LUAN
;
Min LI
;
Rong LIU
Author Information
1. 昆明医科大学第一附属医院老年ICU,云南 昆明 650032
- Keywords:
Omicron variant;
Prognosis;
Cellular immunological indicators
- From:
Journal of Kunming Medical University
2023;44(12):87-94
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of clinical cellular immunity and its relationship with prognosis in elderly patients with severe infection caused by Omicron variant.Methods The clinical data of 53 patients with Omicron variant infection admitted to the geriatric Intensive Care Unit of the First Affiliated Hospital of Kunming Medical University from December 2022 to February 2023 were retrospectively analyzed.The patients were divided into 22 survival cases and 31 death cases for comparison between the two groups.Logistic analysis is adopted to define the omicron variants of elderly severe infections prognostic factors and construct the ROC curve.Results Mu-ltivariate logistic analysis revealed that the independent risk factors were elevated IL-6(P = 0.043)and decreased absolute T lymphocyte count(P = 0.011).AUC value of ROC of IL-6,absolute T lymphocyte count and IL-6 combined with absolute T lymphocyte count was 0.818,0.796 and 0.887.Conclusion Elevated IL-6 and decreased absolute T lymphocyte count are independent risk factors for elderly severe patients with Omicron variant infections.
