Rare Cases of Hepatitis B Virus Infection Combined with Severe Cholinesterase Deficiency not Caused by Liver Dysfunction:Two Case Reports and Literature Review
10.12259/j.issn.2095-610X.S20231210
- VernacularTitle:罕见乙肝病毒感染合并非肝脏合成功能障碍所致的胆碱酯酶极度降低2例个案报道并文献复习
- Author:
Baoli BAI
1
;
Xiaolin KUANG
;
Mingfen HU
;
Guoji CHANG
;
Lu ZHANG
;
Shenghao LI
;
Qingqing WANG
Author Information
1. 云南省传染性疾病临床医学中心/昆明市第三人民医院肝病综合科,云南 昆明 650031
- Keywords:
Cholinesterase;
Butyrylcholinesterase deficiency;
Pseudocholinesterase;
Hereditary metabolic liver disease
- From:
Journal of Kunming Medical University
2023;44(12):59-64
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the hepatitis B virus infection with extreme reduction of cholinesterase(CHE)not caused by liver synthesis dysfunction,and to explore its clinical significance.Methods The clinical data of 2 rare cases hospitalized in the 3rd people's hospital of Kunming in July 2021 and February 2022,including liver function,coagulation function,hepatitis B markers,hepatitis B virus volume,and whole exon sequencing,were collected and analyzed,and literature was reviewed.Results CHE was extremely reduced in 2 patients with HBV infection,liver synthesis function was good,and whole exon sequencing showed the presence of butyrylcholinesterase(BCHE)gene mutation.Conclusion The extremely low CHE in this case is not due to liver function disorder.Exon sequencing detected mutations in the BCHE gene in two patients.Screening for BCHE mutations may be necessary in patients with extremely low cholinesterase levels not due to liver dysfunction.
