The role of epigenetic modifications regulating phase separation in neurodevelopment and neurodisease
10.7644/j.issn.1674-9960.2024.02.011
- VernacularTitle:表观遗传修饰调控相分离在神经发育和神经疾病发生中的作用
- Author:
Heli LIU
1
;
Huihui JIANG
;
Haitao WU
Author Information
1. 南华大学衡阳医学院军事科学院军事医学研究院研究生协作培养基地,湖南衡阳 421001
- Keywords:
epigenetic modification;
phase separation;
biomolecular condensates;
neurodevelopment;
neurodisease
- From:
Military Medical Sciences
2024;48(2):148-153
- CountryChina
- Language:Chinese
-
Abstract:
The important role of liquid-liquid phase separation in a series of biological processes,including regulation of gene transcription and translation,stress response,autophagy and the establishment of synaptic structure,has been widely accepted.Abnormal phase separation is associated with many human diseases,including neurodevelopmental disorders and neurodegenerative diseases.Studies have shown that some proteins associated with epigenetic modifications are also subject to liquid-liquid phase separation,suggesting that epigenetic modifications regulate the development and disease of the nervous system by regulating phase separation.This review summarized the important roles of epigenetic modification and phase separation in neurodevelopment and neurodiseases,and focused on the important roles of proteins related to epigenetic modification with phase separation characteristics.Understanding the correlation between epigenetic modification and phase separation will help fully understand the underlying mechanisms of neurodevelopment and neurodiseases,and will further provide new targets and strategies for the treatment of related diseases.
