Research progress in flavivirus non-structural protein 5
10.7644/j.issn.1674-9960.2024.01.010
- VernacularTitle:黄病毒属非结构蛋白5的研究进展
- Author:
Linlin QIN
1
,
2
;
Dongxing GUO
;
Shulian LI
;
Guang YANG
Author Information
1. 河南大学抗体药物开发技术国家地方联合工程实验室,河南开封 475004
2. 首都医科大学附属北京友谊医院,北京热带医学研究所,北京 100050
- Keywords:
flavivirus;
non-structural protein 5;
methyltransferase;
RNA-dependent RNA polymerase;
virus replication;
immuneevasion;
smallmolecule inhibitor
- From:
Military Medical Sciences
2024;48(1):58-62
- CountryChina
- Language:Chinese
-
Abstract:
The non-structural protein 5(NS5)is a highly conserved protein in the Flavivirus genus,acting as both a methyltransferase(MTase)and an RNA-dependent RNA polymerase(RdRp).It has been well documented that NS5 plays a crucial role in the replication of viral RNA.Recent studies have shown that NS5 proteins from different flaviviruses interact with various proteins in host cells,aiding the virus in evading the immune system.This review summarizes the structure,subcellular localization,and function of NS5 proteins.Additionally,we outline how flavivirus NS5 proteins contribute to viral replication and immune evasion.Lastly,we present the recent developments of specific small molecule inhibitors that target NS5 proteins.
