Research progress on heterogeneity of bone marrow mesenchymal stem cell populations related to hematopoietic system radiation injury repairing

VernacularTitle:造血系统辐射损伤响应相关骨髓间充质干细胞群体异质性研究进展
Author: Fuhao YU ^{1
,

2
,

3} ; Bofeng YIN ; Heng ZHU ; Li DING
Author Information

1. 空军军医大学研究生院,西安 710032
2. 空军特色医学中心血液科,北京 100142
3. 北京辐射医学研究所,北京 100850
Keywords: hematopoietic stem cells; radiation injuries; mesenchymal stem cells; bone marrow microenvironment; damage repair
From: Military Medical Sciences 2023;47(12):956-960
CountryChina
Language:Chinese
Abstract: Efficient treatment of hematopoietic system radiation injuries that occur in medical and military settings is a real problem that has attracted increasing attention.However,current treatments for hematopoietic system radiation injury are lacking.Mesenchymal stem cells(MSCs)are one of the important components of the bone marrow microenvironment.The role of infusion of exogenous MSCs or their exosomes in promoting hematopoietic system radiation damage repair has been extensively reported.However,there have been relatively few studies on the responses of MSCs in situ in bone marrow after radiation injury.This review focuses on the in situ bone marrow MSC populations that are potentially involved in hematopoietic system radiation injury repair and on the heterogeneity of these MSCs.