Guidelines of Prevention and Treatment for NSAID-related Peptic Ulcers.
10.4166/kjg.2009.54.5.309
- Author:
Jun Haeng LEE
1
;
Yong Chan LEE
;
Seong Woo JEON
;
Jeong Wook KIM
;
Sang Woo LEE
Author Information
1. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Review ; English Abstract ; Practice Guideline
- Keywords:
Non-steroidal anti-inflammatory drug;
Peptic ulcer;
Prevention;
Guideline
- MeSH:
Anti-Inflammatory Agents, Non-Steroidal/*adverse effects;
Anti-Ulcer Agents/therapeutic use;
Anticoagulants/adverse effects;
Aspirin/*adverse effects;
Cyclooxygenase 2 Inhibitors/therapeutic use;
Helicobacter Infections/diagnosis/drug therapy;
Helicobacter pylori;
Humans;
Misoprostol/therapeutic use;
Peptic Ulcer/drug therapy/prevention & control/*therapy;
Proton Pump Inhibitors/therapeutic use
- From:The Korean Journal of Gastroenterology
2009;54(5):309-317
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used medications in Korea. Gastrointestinal toxicity, including peptic ulcer, is a common adverse effect of NSAIDs. Risk factors for NSAID-related peptic ulcer include a previous history of peptic ulcer, advanced age, high dose, concomitant use of corticosteroids, anticoagulants, other NSAIDs including low-dose aspirin. Preventive measure(s), such as COX-2 inhibitor, proton pump inhibitor or misoprostrol, should be done for patients requiring NSAID therapy who have high-risk factor(s) for peptic ulcer. Low dose aspirin also increases the risk of peptic ulcer, so preventive measure(s) should be done for high-risk patients. The eradication of Helicobacter pylori is recommended for high-risk NSAID-users. Treatment strategies for peptic ulcers in NSAID users are mostly the same for peptic ulcers in NSAID non-users.
