Transarterial infusion chemotherapy combined with lipiodol chemoembolization for the treatment of advanced colorectal cancer
10.3969/j.issn.1008-794X.2024.02.016
- VernacularTitle:经动脉灌注化疗联合碘化油化疗栓塞治疗晚期结直肠癌
- Author:
Xiaolong DING
1
;
Shuai WANG
;
Yaozhen MA
;
Meipan YIN
;
Tao LIU
;
Shuiling JIN
;
Xiaobing LI
;
Chunxia LI
;
Xinwei HAN
;
Gang WU
Author Information
1. 450052 河南郑州 郑州大学第一附属医院介入科
- Keywords:
infusion chemotherapy;
chemoembolization;
lipiodol;
colorectal cancer;
interventional radiology
- From:
Journal of Interventional Radiology
2024;33(2):186-190
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the clinical safety,feasibility and efficacy of transcatheter arterial infusion chemotherapy(TAI)combined with lipiodol chemoembolization in the treatment of advanced colorectal cancer(CRC).Methods The clinical data of 37 patients with advanced CRC,who received TAI combined with lipiodol chemoembolization at the First Affiliated Hospital of Zhengzhou University of China between June 2016 and December 2022,were retrospectively analyzed.The clinical efficacy was evaluated,the progression-free survival(PFS)and the serious complications were recorded.Results A total of 55 times of TAI combined with lipiodol chemoembolization procedures were successfully accomplished in the 37 patients.The mean used amount of lipiodol emulsion was 2.9 mL(0.8-10 mL).No serious complications such as bleeding and intestinal perforation occurred.The median follow-up time was 24 months(range of 3-48 months).The postoperative one-month,3-month,6-month and 12-month objective remission rates(ORR)were 67.6%(25/37),67.6%(25/37),64.9%(24/37)and 56.8%(21/37)respectively,and the postoperative one-month,3-month,6-month and 12-month disease control rates(DCR)were 91.9%(34/37),91.9%(34/37),89.2%(33/37)and 81.1%(30/37)respectively.The median PFS was 16 months(range of 2-47 months).As of the last follow-up,22 patients survived and 15 patients died of terminal stage of tumor.Conclusion Preliminary results of this study indicate that TAI combined with lipiodol chemoembolization is clinically safe and effective for advanced CRC,and it provide a new therapeutic method for patients with advanced CRC.
