Clinical features of patients with allergic reactions induced by hepatic arterial perfusion chemotherapy and its nursing strategy:preliminary results in 82 patients
10.3969/j.issn.1008-794X.2023.12.016
- VernacularTitle:82例肝动脉灌注化疗致过敏反应患者的临床特征及护理对策
- Author:
Ping LIU
1
;
Xiaoxiao MA
;
Baojiang LIU
;
Xu ZHU
;
Lihong WEN
Author Information
1. 100142 北京 北京大学肿瘤医院(北京市肿瘤防治研究所)介入治疗科,恶性肿瘤发病机制及转化研究教育部重点实验室
- Keywords:
hepatic artery infusion chemotherapy;
allergic reaction;
oxaliplatin;
nursing
- From:
Journal of Interventional Radiology
2023;32(12):1242-1245
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features of patients with allergic reactions induced by hepatic arterial perfusion chemotherapy,and to discuss its nursing strategy.Methods The clinical manifestations,severity grading,time of onset,high-risk drugs,and the initial symptom of anaphylactic shock in 82 patients with allergic reactions were analyzed.Results Of the 82 patients,57(69.5％)had liver metastases from colorectal cancer,aged 42-82 years.Most patients(98.8％)were allergic to oxaliplatin.Degree I allergic reaction was most commonly seen(80.5％),and the clinical manifestations were mainly skin symptoms.Multiple symptoms could occur at the same time.The allergic reactions could occur in various time periods of medication,and anaphylactic shock usually occurred within 30 min after medication,and the initial symptom was atypical.Conclusion Oxaliplatin is a common drug that may cause allergic reactions in patients receiving hepatic artery infusion chemotherapy.Nursing staff should be familiar with the relevant drug allergic reactions,especially the clinical symptoms,features,and nursing measures of anaphylactic shock,so as to ensure the safety of patients.(J Intervent Radiol,2023,32:1242-1245)
