Stereotactic body radiotherapy versus radiofrequency ablation for hepatocellular carcinoma:a meta-analysis
10.3969/j.issn.1008-794X.2023.12.015
- VernacularTitle:对比立体定向放射治疗与射频消融治疗肝细胞癌效果的Meta分析
- Author:
Wenting DU
1
;
Yu HE
;
Yue WU
;
Bingxin YU
;
Yang LU
;
Yuanqiang LIN
;
Cuiping ZHAN
;
Chunxiang JIN
Author Information
1. 130033 吉林长春 吉林大学中日联谊医院超声科
- Keywords:
stereotactic body radiotherapy;
radiofrequency ablation;
hepatocellular carcinoma;
meta-analysis
- From:
Journal of Interventional Radiology
2023;32(12):1233-1241
- CountryChina
- Language:Chinese
-
Abstract:
Objective Stereotactic body radiotherapy(SBRT)and radiofrequency ablation(RFA)are primary treatments for hepatocellular carcinoma(HCC)at present.However,the effect of these treatments in clinical trails are rather controversial.The purpose of this paper is to conduct a meta-analysis on the clinical effect and related complications of SBRT and RFA for HCC.Methods A computerized retrieval of academic papers concerning the treatment effect of SBRT and RFA for HCC from the databases of PubMed,Embase,Cochrane Library,Scopus,Web of Science,CBM,CNKI,Wanfang database,VIP was conducted.The retrieval time period was from the establishment of the database to June 2022.Stata14.0 software was used to make meta-analysis.Results A total of 14 retrospective studies including 6 806 patients were included in this analysis.The results of combined hazard ratio(HR)based on overall survival(OS)showed that the OS rate of SBRT was lower than that of RFA(HR=1.25,95％CI=1.10-1.43,12=0％,P=0.000 9),while the results of combined HR of local control(LC)rate indicated that SBRT had a better therapeutic effect(HR=0.61,95％CI=0.47-0.78,I2=0％,P=0.000 1).Subgroup analysis revealed that the combined HR of LC rate favored the performance of SBRT for patients with tumor diameter larger than 2 cm(HR=2.64,95％CI=1.56-4.48,I=0％,P=0.000 3).No statistically significant difference in the incidence of late serious adverse reactions existed between SBRTgroup and RFA group(OR=1.01,95％CI=0.59-1.73,I2=30％,P=0.97).Conclusion SBRT is superior to RFA in controlling local HCC lesions,especially in patients whose tumor diameter is larger than 2 cm,although it does not show certain advantages in the survival benefit.(J Intervent Radiol,2023,32:1233-1241)
