Research progress on the effect of α7 nicotinic acetylcholine receptor on perioperative neurocognitive function
10.11855/j.issn.0577-7402.1157.2022.1006
- VernacularTitle:α7烟碱型乙酰胆碱受体对围手术期神经认知功能的影响研究进展
- Author:
Shang-Kun SI
1
;
Ying-Xue XU
;
Wei-Liang ZHANG
;
Jia-Fu JI
;
Dong-Bin ZHANG
Author Information
1. 山东中医药大学中医学院,山东济南 250014
- Keywords:
α7 nicotinic acetylcholine receptor;
perioperative period;
neurocognitive function;
cholinergic anti-inflammatory pathway;
central nerve system diseases
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(3):343-348
- CountryChina
- Language:Chinese
-
Abstract:
α7 nicotinic acetylcholine receptor(α7nAChR)is widely expressed in the central nervous system and immune system,and plays a neuro-immunoregulatory role.On the one hand,α7nAChR is involved in the transmission of neurotransmitters,the conduction of excitatory signals and the maintenance of synaptic plasticity,which is of great significance for maintaining the normal and stable neurocognitive function.On the other hand,as an important part of the cholinergic anti-inflammatory pathway,α7nAChR is involved in the regulation of physiological and pathological processes such as inflammatory response,oxidative stress,apoptosis and autophagy in the central system,and plays an immunomodulatory and neuroprotective role,thus being potential target for improving perioperative neurocognitive function.This article reviews the biological characteristics of α7nAChR and its effect on perioperative neurocognitive function,in order to provide ideas and methods for clinical improvement of perioperative neurocognitive function in surgical patients.
