Characteristics of T cell immune responses in adults inoculated with 2 doses of SARS-CoV-2 inactivated vaccine for 12 months
10.11855/j.issn.0577-7402.0075.2023.0427
- VernacularTitle:成人接种2剂新冠灭活疫苗12个月后T细胞免疫应答特点
- Author:
Jing WANG
1
,
2
;
Ya-Qun LI
;
Hai-Yan WANG
;
Yao-Ru SONG
;
Jing LI
;
Wen-Xin WANG
;
Lin-Yu WAN
;
Chun-Bao ZHOU
;
Xing FAN
;
Fu-Sheng WANG
Author Information
1. 中国科学技术大学附属第一医院,安徽合肥 230001
2. 解放军总医院第五医学中心感染病医学部/国家感染性疾病临床医学研究中心,北京 100039
- Keywords:
severe acute respiratory syndrome coronavirus 2;
inactivated vaccine;
T cell immune response
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(2):165-170
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the characteristics of different antigen-specific T cell immune responses to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)after inoculation with 2 doses of SARS-CoV-2 inactivated vaccine for 12 months.Methods Fifteen healthy adults were enrolled in this study and blood samples collected at 12 months after receiving two doses of SARS-CoV-2 inactivated vaccine.The level and phenotypic characteristics of SARS-CoV-2 antigen-specific T lymphocytes were detected by activation-induced markers(AIM)based on polychromatic flow cytometry.Results After 12 months of inoculation with 2 doses of SARS-CoV-2 inactivated vaccine,more than 90%of adults had detectable Spike and Non-spike antigen-specific CD4+ T cells immune responses(Spike:14/15,P=0.0001;Non-spike:15/15,P<0.0001).80%of adults had detectable Spike and Non-spike antigen-specific CD8+ T cells immune responses(Spike:12/15,P=0.0463;Non-spike:12/15,P=0.0806).Antigen-specific CD4+ T cells induced by SARS-CoV-2 inactivated vaccination after 12 months were composed of predominantly central memory(CM)and effector memory 1(EM1)cells.On the other hand,in terms of helper subsets,antigen-specific CD4+ T cells mainly showed T helper 1/17(Th1/17)and T helper 2(Th2)phenotypes.Conclusions SARS-CoV-2 inactivated vaccination generates durable and extensive antigen-specific CD4+ T cell memory responses,which may be the key factor for the low proportion of severe coronavirus disease 2019(COVID-19)infection in China.
