Prognostic significance of MyD88L265P and CD79B mutations in primary central nervous system lymphoma
10.11855/j.issn.0577-7402.1223.2023.0528
- VernacularTitle:MyD88L265P及CD79B基因突变对原发性中枢神经系统淋巴瘤预后的影响
- Author:
Hao-Yun JIANG
1
;
Qi-Qi JIN
;
Li-Tian ZHANG
;
Cui-Cui LI
;
Ning-Ning YUE
;
Chong-Yang WU
Author Information
1. 兰州大学第二医院血液科,甘肃兰州 730030
- Keywords:
primary central nervous system lymphoma;
MyD88 mutation;
CD79B mutation;
prognosis
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(1):57-63
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between MyD88L265P and CD79B mutations in tumor tissue and the prognosis of primary central nervous system lymphoma(PCNSL).Methods 18 PCNSL patients with normal immune function(no history of HIV infection and immunosuppressants administration)who were diagnosed by craniotomy or stereotaxic biopsy in the Second Hospital of Lanzhou University from August 2018 to November 2020 were retrospectively analyzed.Real-time quantitative PCR and first-generation sequencing techniques were respectively used to detect MyD88L265P and CD79B mutations in tumor tissues of 18 PCNSL patients.Univariate analysis and Cox regression multivariate analysis were performed for indicators that may be associated with first progression-free survival(PFS)and overall survival in PCNSL.Results The mutation rate of MyD88L265P was 38.9%,the mutation rate of CD79B was 33.3%,and the co-mutation rate of MyD88L265P/CD79B was 27.8%in PCNSL tissue of 18 patients.Univariate analysis showed that the PCNSL patients with multiple lesions,deep involvement of lesions,and tissue CD79B mutation had a statistically significant shorter time of PFS(P<0.05).Multivariate analysis showed that deep lesion involvement(HR=0.135,95%CI 0.023-0.799,P<0.05)and CD79B mutation(HR=0.149,95%CI 0.028-0.800,P<0.05)in PCNSL tissue were independent prognostic factors for PCNSL patients.Conclusion The frequency of MyD88L265P and CD79B mutations was high in tumor tissues of 18 PCNSL patients,and these two gene mutations may be associated with poor prognosis of PCNSL,especially CD79B mutation.
