Research progress on effect of unfolded protein response in heat stroke
10.11855/j.issn.0577-7402.0216.2023.0501
- VernacularTitle:未折叠蛋白反应在热射病中的作用研究进展
- Author:
Yu-Liang PENG
1
,
2
;
Jiu-She KOU
;
You WU
;
Zong-Ping FANG
;
Xi-Jing ZHANG
Author Information
1. 陕西中医药大学第二附属医院针灸康复科,陕西咸阳 712000
2. 空军军医大学第一附属医院重症医学科,陕西西安 710032
- Keywords:
heat stroke;
unfolded protein response;
mitochondria;
endoplasmic reticulum stress
- From:
Medical Journal of Chinese People's Liberation Army
2023;48(12):1486-1491
- CountryChina
- Language:Chinese
-
Abstract:
Heat stroke(HS)is a serious life-threatening disease caused by heat injury and characterized by a core body temperature>40℃with central nervous system dysfunction and multi-organ failure.The main pathophysiological manifestations of HS are the thermal acute phase response and thermoregulatory imbalance.Proteins are particularly sensitive to heat,and the thermal environment can cause massive protein denaturation,resulting in the deposition of unfolded and misfolded proteins in the cytoplasm,causing cellular dysfunction and even death.The unfolded protein response(UPR),mainly divided into the endoplasmic reticulum UPR and the mitochondrial UPR,is an important physiological process that helps proteins to fold correctly or degrade irretrievably denatured proteins.This paper summarizes the regulatory mechanisms of UPR,the relationship between UPR and severe diseases,as well as the relationship between HS and UPR to provide new ideas for the treatment of HS.
