Research progress on the role of Asprosin in germ cell development
10.16352/j.issn.1001-6325.2024.04.0558
- VernacularTitle:Asprosin在生殖细胞发育中作用的研究进展
- Author:
Zhiqin XU
1
;
Xiao TAN
Author Information
1. 南京医科大学第二附属医院 心血管内科,江苏 南京 210011
- Keywords:
Asprosin;
polycystic ovary syndrome(PCOS);
germ cell
- From:
Basic & Clinical Medicine
2024;44(4):558-561
- CountryChina
- Language:Chinese
-
Abstract:
Asprosin is a protein-like hormone composed of 140 amino acids,which is mainly secreted by adipo-cytes.Polycystic ovary syndrome(PCOS)and asthenospermia are common causes of infertility.Asprosin promotes the production of estradiol in small granular cells induced by follicle stimulating hormone(FSH)and progesterone in small granular cells induced by insulin-like growth factor 1(IGF-1),which functions in the growth of ovarian folli-cles and ovulation of dominant follicles.Asprosin promotes the secretion of sex hormones and the production of nu-trients,increasing the number,survival time and motility of sperms by acting on the hypothalamus and testicles.Asprosin is involved in regulation of follicle growth and spermatogenesis,so this finding may potentially support the development of new strategies for the treatment of infertility.
