Research advances on the age-related macular degeneration

VernacularTitle:年龄相关性黄斑变性的研究进展
Author: Dandan WEI ¹ ; Yuhan SONG ; Qi WANG ; Shulan SU ; Yue ZHU ; Jin'ao DUAN
Author Information

1. 南京中医药大学中药资源产业化与方剂创新药物国家地方联合工程研究中心/江苏省中药资源产业化过程协同创新中心/江苏省方剂高技术研究重点实验室,江苏南京 210023
Keywords: age-related macular degeneration(AMD); retina; retinal pigment epithelial cells(RPE); cellular senescence
From: Basic & Clinical Medicine 2024;44(4):553-557
CountryChina
Language:Chinese
Abstract: Age-related macular degeneration(AMD)is a serious threat to the visual health of the elderly,and the dysfunction of retinal pigment epithelial cells(RPE)is a significant etiology risk.Aging process leads to RPE repli-cation senescence,and some environment factors like light exposure and cigarette exposure may lead to RPE stress premature aging,and the decreased lysosomal digestion ability of senescent RPE cells may lead to the accumulation of lipofuscin,triggering the occurrence of early AMD.A series of homeostatic imbalances in aging retina,such as cell senescence-renewal imbalance,oxidative stress-antioxidant imbalance,chronic inflammatory-anti-inflammatory imbalance,intestinal barrier and intestinal microbiota imbalance and pro-angiogenesis-antiangiogenic imbalance all contribute to the development of AMD.