Advances on reprogramming of fatty acid metabolism in pulmonary fibrosis
10.16352/j.issn.1001-6325.2024.04.0548
- VernacularTitle:脂肪酸代谢重编程在肺纤维化中的研究进展
- Author:
Lu BAI
1
;
Jiaxin WANG
;
Xue WANG
;
Wei ZENG
;
Meiyue SONG
;
Tiantian ZHANG
;
Jing WANG
Author Information
1. 中国医学科学院基础医学研究所 北京协和医学院基础学院 呼吸与共病全国重点实验室,北京 100005
- Keywords:
fatty acids;
pulmonary fibrosis;
metabolic reprogramming
- From:
Basic & Clinical Medicine
2024;44(4):548-552
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary fibrosis is a progressive interstitial fibrotic lung disease with high mortality.Its pathogenesis is complex and involves the reprogramming of fatty acid metabolism.This reprogramming includes changes in de novo fatty acid synthesis,uptake,oxidation,and derivatives.It crucially influences alveolar epithelial cell survival,macrophage polarization,and fibroblast activation,thereby playing a significant role in either exacerbating or miti-gating the disease.Understanding and intervening in the reprogramming of fatty acid metabolism offers potential strategies for prevention,diagnosing and treatment of pulmonary fibrosis.
