Association of NSE level with clinical features in pheochromocytoma/paraganglioma

VernacularTitle:嗜铬细胞瘤/副神经节瘤患者血NSE水平与临床特征的关系
Author: Tianyi LI ¹ ; Wenqian ZHANG ; Yinghan CHEN ; Yue ZHOU ; Yunying CUI ; Yu WANG ; Anli TONG
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1. 中国医学科学院北京协和医学院北京协和医院内分泌科国家卫生健康委员会内分泌重点实验室,北京 100730
Keywords: neuron specific enolase; pheochromocytoma and paraganglioma; catecholamine; metastasis
From: Basic & Clinical Medicine 2024;44(4):533-538
CountryChina
Language:Chinese
Abstract: Objective To study the relationship between serum neuron-specific enolase(NSE)and clinical features of pheochromocytoma/paraganglioma(PPGL).Methods Totally 501 PPGL patients diagnosed from January 2019 to December 2022 were divided into normal NSE group(NSE≤16.3 ng/mL)and elevated NSE group(NSE＞16.3 ng/mL).The clinical characteristics were compared between the two groups.Results Compared with normal NSE group,patients in the elevated NSE group had larger diameter in primary tumor(5.00 cm vs.4.60 cm),higher 24-hour urinary norepinephrine(NE)and 24-hour urinary dopamine(DA)levels,and a higher rate of metasta-sis(31.6%vs.13.7%)(P＜0.05).NSE level was positively correlated with the primary tumor size(r=0.131,P＜0.05),24-hour urinary NE level(r=0.195,P＜0.05)and 24-hour urinary DA level(r=0.119,P＜0.05).Conclusions The level of NSE is related to tumor size,secretion function and metastasis in PPGL patients.