Research progress on the mechanism of annexin A family members in breast cancer
10.16352/j.issn.1001-6325.2024.03.0393
- VernacularTitle:膜联蛋白A家族成员在乳腺癌中作用机制的研究进展
- Author:
Lu NAN
1
;
Menjie GUO
;
Yanan GAO
;
Hongyan JIA
Author Information
1. 山西医科大学 第一临床医学院,山西 太原 030001
- Keywords:
annexins A family;
breast cancer;
tumorigenesis
- From:
Basic & Clinical Medicine
2024;44(3):393-397
- CountryChina
- Language:Chinese
-
Abstract:
The annexins(ANX)family is widely present in the cell membrane,cytoplasm or extracellular matrix.As key tumor regulatory molecules,annexins A(ANX A)family can promote or inhibit invasion and metastasis of breast cancer cells by influencing cell membrane and cytoskeleton formation and participating in signaling pathways.ANX A family also plays a role in the apoptosis of breast cancer cells by regulation of pro-apoptotic proteins and cell cycle independent kinases(CDKs)and related pathways.In addition,ANX A family can also promote therapeutic resistance to a large number of drugs.For instance,ANX A1 enhances triple-negative breast cancer resistance by in-ducing epithelial-mesenchymal transformation.ANX A4 induces resistance by forming ANX A4-Fhit complexes and secretion of exosomes containing ANX A6 promotes paclitaxel resistance in breast cancer cells in a YAP1-dependent manner.So ANX A family may be a new target for breast cancer treatment.
