Research progress on P2X7 receptor in cancer pain
10.16352/j.issn.1001-6325.2024.03.0389
- VernacularTitle:P2X7受体在癌痛中作用的研究进展
- Author:
Zhongwen ZHANG
1
;
Rui ZHAO
;
Haolong ZHANG
;
Yuting YANG
;
Jinxia BAI
;
Haoling ZHANG
;
Wei WANG
Author Information
1. 甘肃中医药大学 公共卫生学院,甘肃 兰州 730000
- Keywords:
P2X7 receptor;
cancer pain;
glial cell;
P2X7 antagonist
- From:
Basic & Clinical Medicine
2024;44(3):389-392
- CountryChina
- Language:Chinese
-
Abstract:
The activation of the P2X7 receptor as an ATP-gated ion channel,triggers the release of pro-inflammato-ry cytokines in tumor carring individuals and stimulate excitation of injury-causing neurons,thereby exacerbating the transmission of pain.In preclinical cancer pain models,it has the potential to serve as a new therapeutic target for cancer pain management.
