Research progress on the role of ferroptosis in the pathogenesis of non-alcoholic fatty liver disease
10.16352/j.issn.1001-6325.2024.02.0260
- VernacularTitle:铁死亡在非酒精性脂肪性肝病发病中作用的研究进展
- Author:
Yanxin XIAO
1
;
Yan LIU
;
Lingling XU
;
Yaru ZHOU
Author Information
1. 保定市第一中心医院 内分泌科,河北 保定 071000
- Keywords:
ferroptosis;
non-alcoholic fatty liver disease;
lipid peroxidation;
iron overload
- From:
Basic & Clinical Medicine
2024;44(2):260-264
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a new type of cell death proposed in recent years,and its main characteristics are iron overload and lipid peroxidation.Ferroptosis is involved in the occurrence and development of non-alcoholic fatty liv-er disease(NAFLD).Iron overload can generate a large amount of reactive oxygen species through the Fenton reac-tion.Under the action of lipoxygenase,the unsaturated fatty acids on the liver cell membrane undergo lipid peroxi-dation,which induces liver cell death and leads to the occurrence of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis.Blocking ferroptosis may provide one of the therapeutic strategies to protect liver cells.
