Comparison of Extended-Spectrum beta-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae Bloodstream Infection Epidemiology.
10.14192/kjnic.2014.19.2.45
- Author:
Phill Hoon YOON
;
Eun Bin CHO
;
Su Ji KIM
;
Yeon Hee LEE
;
Yiel Hea SEO
;
Yoon Soo PARK
- Publication Type:Original Article
- Keywords:
Bloodstream infection;
Epidemiology;
ESBL;
Escherichia coli;
Klebsiella pneumoniae
- MeSH:
Anti-Bacterial Agents;
beta-Lactamases;
Biliary Tract;
Catheters;
Comorbidity;
Epidemiology*;
Escherichia coli*;
Humans;
Klebsiella pneumoniae*;
Pneumonia;
Respiratory System;
Respiratory Tract Infections;
Retrospective Studies;
Skin;
Soft Tissue Infections;
Urinary Tract Infections
- From:Korean Journal of Nosocomial Infection Control
2014;19(2):45-51
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae are main pathogens of bloodstream infection. We compared the epidemiology of ESBL-producing E. coli and K. pneumoniae. METHODS: From January 2003 through March 2007, we retrospectively investigated the clinical characteristics and comorbidities of patients with bloodstream infection by ESBL-producing E. coli and K. pneumoniae. RESULTS: During the study period, 79 patients (54 with E. coli and 25 with K. pneumoniae) with blood cultures positive for ESBL-producing E. coli or K. pneumoniae were studied. When comparing the source of bloodstream infections, urinary tract infections (UTIs) were more commonly caused by E. coli (24% vs. 0; P=0.007), and respiratory tract and soft tissue infection (36% vs. 15%; P=0.04, 12% vs. 0; P=0.03, respectively) were more commonly associated with K. pneumoniae. Among hospital-acquired bloodstream infection, third-generation cephalosporin was more commonly used in patients with E. coli than patients with K. pneumoniae (81% vs. 24%, P<0.001). Medical devices (central venous catheter and urinary catheter) were more commonly used in patients with K. pneumoniae. CONCLUSION: ESBL-producing E. coli bloodstream infection is more common in urinary tract infections. ESBL-producing K. pneumoniae is more common in respiratory tract infections and in skin and soft tissue infections. In hospital-acquired infections, ESBL-producing E. coli bloodstream infection is more common in biliary tract infection. ESBL-producing E. coli was more commonly associated with prior frequent antibiotics use and K. pneumoniae was more commonly associated with use of medical devices.
