Immunological abnormalities in patient with IgA nephropathy.
- Author:
Chun Gyoo IHM
1
;
Jeong Taek WOO
;
Young Woon CHANG
;
O Sun KWON
;
Myung Jae KIM
Author Information
- Publication Type:Original Article
- Keywords: IgA nephropathy; helper T cell; suppressor T cell; Natural Killer (NK) cell activity
- MeSH: B-Lymphocytes/immunology; Glomerulonephritis, IGA/*immunology/pathology; Humans; Killer Cells, Natural/immunology; Neutrophils/immunology; *Phagocytosis; T-Lymphocytes/*immunology; T-Lymphocytes, Regulatory/immunology
- From:Journal of Korean Medical Science 1986;1(1):43-48
- CountryRepublic of Korea
- Language:English
- Abstract: T cell immunity and phagocytic activity were studied in the blood of patients with IgA nephropathy in order to clarify their roles in the pathogenesis of IgA nephropathy. The percentages of total T lymphocytes, helper T cell and suppressor T cells were significantly reduced in patients. A significantly elevated helper T cell/suppressor T cell ratio in patients showed a predominant reduction in suppressor T cells. There was a significant relationship between histologic findings and helper T cell/suppressor T cell ratio in patients. Natural Killer (NK) cell activity was significantly reduced but the lymphocyte response after phytohemagglutinin (PHA) stimulation was not in patients. ConA-induced suppressor cell activity was not depressed despite of a decrease in suppressor T cells in patients. Phagocytic activity of polymorphonuclear leucocytes (PMNs) ingesting yeasts was significantly reduced in patients. Also an inverse correlation was found between serum IgA levels and phagocytic activity of PMN. It is concluded that suppressor T cell defects, depressed phagocytic activity and impaired NK cell activity may play a role in the pathogenesis of IgA nephropathy.
