Progress of the effect of hydroxyacyl-coenzyme A dehydrogenase in cancer development and its mechanism
10.16352/j.issn.1001-6325.2024.01.0119
- VernacularTitle:羟酰辅酶A脱氢酶在癌中作用机制的研究进展
- Author:
Guojia WU
1
;
Shujie ZHAI
;
Xiao SUN
;
Yiran HUANG
;
Yongmei LI
;
Li SUN
Author Information
1. 天津医科大学 基础医学院 病原生物学系, 天津 300211
- Keywords:
hydroxyacyl-coenzyme A dehydrogenase;
lipid metabolism;
fatty acid β-oxidation;
tumor suppressor gene;
tumor marker
- From:
Basic & Clinical Medicine
2024;44(1):119-123
- CountryChina
- Language:Chinese
-
Abstract:
A close relationship between fatty acid metabolism and cancer development is well-established.The hydroxyacyl-coenzyme a dehydrogenase(HADH),a key enzyme in fatty acid beta-oxidation,has recently been identified as an anti-oncogenic factor in various cancers and an oncogenic factor in conditions like acute myeloid leukemia.In cancer cells,HADH not only directly catalyzes fatty acid beta-oxidation but also indirectly influences multiple signaling pathways such as PPAR,TNF-α,JAK-STAT3,PI3K/Akt,IFN-γ,MAPK,and non-canonical Wnt signaling pathways,affecting cancer cell proliferation and migration.HADH shows promise as a potential tumor biomarker for diagnosis,treatment,and prognosis in different cancer types,holding significant clinical value.
