Research progress on the role of thrombospondin 2 in malignant tumors
10.16352/j.issn.1001-6325.2023.12.1881
- VernacularTitle:血小板反应蛋白2在恶性肿瘤中作用的研究进展
- Author:
Jiajunyan MA
1
,
2
;
Tiannan RUI
;
Yongsheng ZHANG
Author Information
1. 苏州大学附属第二医院 病理科,江苏 苏州 215004
2. 苏州大学 苏州医学院 临床医学系,江苏 苏州 215123
- Keywords:
thrombospondin;
thrombospondin 2;
carcinoma
- From:
Basic & Clinical Medicine
2023;43(12):1881-1885
- CountryChina
- Language:Chinese
-
Abstract:
Thrombospondin 2(THBS2)is a matrix cell calcium-binding glycoprotein that interacts with a variety of growth factors,receptors,matrix molecules or proteases on the extracellular matrix and cell surface.THBS2 can be activated by N6-methyladenosyl RNA methylase,and mediates tumor proliferation,migration and invasion by re-modeling the tumor microenvironment and participating in multiple cell signaling pathways.THBS2 could be used as a diagnostic and prognostic indicator for a variety of tumors,and is expected to become a new target for malignant tumor treatment.
