Establishment of reference intervals of squamous cell carcinoma antigen for healthy population in Nanning region
10.16352/j.issn.1001-6325.2023.12.1796
- VernacularTitle:南宁地区健康人群血清鳞状上皮细胞癌抗原参考区间的建立
- Author:
Dongyi ZHOU
1
;
Yuhong WEI
;
Liling YI
;
Shangmou WEI
;
Chunling ZHU
;
Sufang YANG
;
Qiliu PENG
Author Information
1. 广西中医药大学附属国际壮医医院 检验科,广西 南宁 530201
- Keywords:
squamous cell carcinoma antigen;
reference interval;
squamous cell carcinoma
- From:
Basic & Clinical Medicine
2023;43(12):1796-1800
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a reference intervals(RIs)of serum squamous cell carcinoma antigen(SCC-Ag)in healthy population in Nanning region and provide clinical evidence to support diagnosis and prognosis of squamous cell carcinoma.Methods A total of 10 197 reference individuals who joined a routine physical examina-tion in the Health Management Center of Guangxi International Zhuang Medical Hospital from March 2019 to De-cember 2021 were collected.The level of serum SCC-Ag was detected by chemiluminescence microparticle immuno-assay.The Mann-Whitney U test was applied to compare the differences in serum SCC level between genders or ad-jacent age groups.The unilateral 95th percentile determined the upper limit of the RIs by the nonparametric method.Another 1 035 healthy subjects with the same conditions as the reference population were selected for refer-ence validation.Results The serum SCC-Ag level showed a skewed distribution(Z＝0.08,P＜0.05).The ser-um SCC-Ag level of males was considerably higher than that of females.There was significant difference in serum SCC-Ag level between males aged 18－30 and 31－40,51－60 and 61－90(P＜0.05).There was significant difference in serum SCC-Ag level between females aged 18－30 and 31－40,31－40 and 41－50,51－60 and 61－ 90(P＜0.05).The reference intervals of serum SCC-Ag was as follows:0－1.64 ng/mL for males and females aged 18－30 years;0－1.57 ng/mL and 0－1.70 ng/mL for males aged 31－60 years and 61－90 years,respec-tively;0－1.50 ng/mL,0－1.52 ng/mL and 0－1.42 ng/mL for females aged 31－40 years,41－60 years and 61－90 years,respectively.Conclusions The RIs of serum SCC-Ag in healthy population in the Nanning region are successfully established according to different genders and ages.
