Hemodynamics and arrhythmia disorder caused by lithium poisoning:A case report
10.11817/j.issn.1672-7347.2024.230367
- VernacularTitle:锂中毒导致心律失常、血流动力学障碍1例
- Author:
Yujue WANG
1
;
Lijun OUYANG
;
Xiaoqian MA
;
Danyan XU
;
Xiaogang CHEN
;
Ying HE
Author Information
1. 中南大学湘雅二医院精神科,国家精神心理疾病临床医学研究中心,精神病学与精神卫生学湖南省重点实验室,长沙 410011
- Keywords:
lithium carbonate;
bipolar affective disorder;
cardiac arrhythmia;
sinus node dysfunction;
lithium intoxication
- From:
Journal of Central South University(Medical Sciences)
2024;49(1):153-158
- CountryChina
- Language:Chinese
-
Abstract:
Bipolar affective disorder refers to a category of mood disorders characterized clinically by the presence of both manic or hypomanic episodes and depressive episodes.Lithium stands out as the primary pharmacological intervention for managing bipolar affective disorder.However,its therapeutic dosage closely approaches toxic levels.Toxic symptoms appear when the blood lithium concentration surpasses 1.4 mmol/L,typically giving rise to gastrointestinal and central nervous system reactions.Cardiac toxicity is rare but serious in cases of lithium poisoning.The study reports a case of a patient with bipolar affective disorder who reached a blood lithium concentration of 6.08 mmol/L after the patient took lithium carbonate sustained-release tablets beyond the prescribed dosage daily and concurrently using other mood stabilizers.This resulted in symptoms such as arrhythmia,shock,impaired consciousness,and coarse tremors.Following symptomatic supportive treatment,including blood dialysis,the patient's physical symptoms gradually improved.It is necessary for clinicians to strengthen the prevention and recognition of lithium poisoning.
