Clinical applications of abnormal DNA methylation in chronic myeloid leukemia
10.11817/j.issn.1672-7347.2024.230336
- VernacularTitle:异常DNA甲基化在慢性髓系白血病中的临床应用
- Author:
Lingyan ZHOU
1
;
Xiaocheng YIN
Author Information
1. 南华大学衡阳医学院附属第一医院儿科,湖南 衡阳 421600
- Keywords:
chronic myeloid leukemia;
DNA methylation;
demethylation drugs;
epigenetics
- From:
Journal of Central South University(Medical Sciences)
2024;49(1):122-127
- CountryChina
- Language:Chinese
-
Abstract:
DNA methylation,a crucial biochemical process within the human body,fundamentally alters gene expression without modifying the DNA sequence,resulting in stable changes.The changes in DNA methylation are closely related to numerous biological processes including cellular proliferation and differentiation,embryonic development,and the occurrence of immune diseases and tumor.Specifically,abnormal DNA methylation plays a crucial role in the formation,progression,and prognosis of chronic myeloid leukemia(CML).Moreover,DNA methylation offers substantial potential for diagnosing and treating CML.Accordingly,understanding the precise mechanism of DNA methylation,particularly abnormal changes in the methylation of specific genes in CML,can potentially promote the development of novel targeted therapeutic strategies.Such strategies could transform into clinical practice,effectively aiding diagnosis and treatment of CML patients.
