Mechanisms of the role of proto-oncogene activation in promoting malignant transformation of mature B cells
10.11817/j.issn.1672-7347.2024.230304
- VernacularTitle:原瘤基因激活诱导成熟B细胞恶变的作用机制
- Author:
Ruiqi ZHOU
1
;
Jiaojiao GUO
;
Xiangling FENG
;
Wen ZHOU
Author Information
1. 中南大学基础医学院肿瘤研究所,长沙 410078
- Keywords:
proto-oncogene activated;
B cell malignant transformation;
mature B cell neoplasms
- From:
Journal of Central South University(Medical Sciences)
2024;49(1):113-121
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumors continue to pose a significant threat to human life and safety and their development is primarily due to the activation of proto-oncogenes and the inactivation of suppressor genes.Among these,the activation of proto-oncogenes possesses greater potential to drive the malignant transformation of cells.Targeting oncogenes involved in the malignant transformation of tumor cells has provided a novel approach for the development of current antitumor drugs.Several preclinical and clinical studies have revealed that the development pathway of B cells,and the malignant transformation of mature B cells into tumors have been regulated by oncogenes and their metabolites.Therefore,summarizing the key oncogenes involved in the process of malignant transformation of mature B cells and elucidating the mechanisms of action in tumor development hold significant importance for the clinical treatment of malignant tumors.
